Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Histamine and Antihistamines in Atopic Dermatitis

Filename 55. Buddenkotte,Maurer, Hist. and AH in AD,Adv Exp Med Biol. 2011.pdf
Filesize 271 KB
Version r.055
Date added June 26, 2020
Downloaded 0 times
Category Reviews
Tags antihistamines, atopic dermatitis, histamine
Authors Buddenkotte, J., Maurer, M., and Steinhoff, M.
Citation Buddenkotte, J., Maurer, M., and Steinhoff, M.: Histamine and antihistamines in atopic dermatitis. Adv. Exp. Med. Biol. 2011: 709; 73-80.
Corresponding authors Steinhoff, M.
DocNum R.55
DocType PDF
Edition; Page 709; 73-80
IF 1.37
Publisher Adv. Exp. Med. Biol.
ReleaseDate 2011

Itching (pruritus) is perhaps the most common symptom associated with numerous skin diseases and can be a lead symptom of extracutaneous disease (e.g., malignancy, infection, metabolic dis‑ orders). Also in atopic dermatitis itching sensations constitute one of the most prominent and distressing features. However, the most characteristic response to itching is the scratch reflex: a more or less voluntary, often sub‑conscious motor activity, to counteract the itch by slightly painful stimuli. The benefit of a short‑termed relieve from itching through this scratch reflex though is counteracted by a simultaneous damage of the epidermal layer of the skin which leads to increased transepidermal water loss and drying, which in turn results in a cycle of more itching and more scratching. A be‑ wilderingly wide range of peripheral itch‑inducing stimuli generated within or administered to the skin are able to trigger pruritus, one of them being histamine. Based on early experiments, histamine has been suggested to may play a key role in the pathogenesis of AD. This is reflected by a history for antihistamines in the therapeutic medication of AD patients. Antihistamines are believed to share a common antipruritic effect and therefore are prescribed to almost any AD patient suffering from itch to act alleviating. This general assumption has been proved to be wrong. To assess the benefit of antihistamines in the treatment of AD in a better way, their mechanisms and specific effects need to be understood more precisely. In particular their precise indication is crucial for successful use. This book chapter will therefore summarize and assess the role of histamine in AD and the efficacy of antihistamines in its treatment based on results of basic research and clinical studies.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429