Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Human mast cell tryptase is a potential treatment for snakebite envenoming across multiple snake species

Filename 312. Kolkhir et al., Man CSU worldwide, WAO J 2018.pdf
Filesize 608 KB
Version o.321
Date added June 13, 2020
Downloaded 0 times
Category Original Work
Tags antivenom, mast cell, proteases, snakes, venom
Authors Anderson, E., Stavenhagen, K., Kolarich, D., Sommerhoff, C. P., Maurer, M. and Metz, M.
Citation Anderson, E., Stavenhagen, K., Kolarich, D., Sommerhoff, C. P., Maurer, M. and Metz, M.: Human mast cell tryptase is a potential treatment for snakebite envenoming across multiple snake species. Front. Immunol. 2018: 9; 1532.
Corresponding authors Metz, M.
DocNum O.321
DocType PDF
Edition; Page 9; 1532
IF 4.72
Publisher Front. Immunol.
ReleaseDate 2018

Snake envenoming is a serious and neglected public health crisis that is responsible for as many as 125,000 deaths per year, which is one of the reasons the World Health Organization has recently reinstated snakebite envenoming to its list of category A neglected tropical diseases. Here, we investigated the ability of human mast cell prote- ases to detoxify six venoms from a spectrum of phylogenetically distinct snakes. To this end, we developed a zebra sh model to assess effects on the toxicity of the venoms and characterized the degradation of venom proteins by mass spectrometry. All snake venoms tested were detoxi ed by degradation of various venom proteins by the mast cell protease tryptase β, and not by other proteases. Our data show that recombinant human tryptase β degrades and detoxi es a phylogenetically wide range of venoms, indicating that recombinant human tryptase could possibly be developed as a universal antidote to venomous snakebites.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429