Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Human mast cell tryptase is a potential treatment for snakebite envenoming across multiple snake species
Filename | 312. Kolkhir et al., Man CSU worldwide, WAO J 2018.pdf |
Filesize | 607.72 KB |
Version | o.321 |
Date added | June 13, 2020 |
Downloaded | 1 time |
Category | Original Work |
Tags | antivenom, mast cell, proteases, snakes, venom |
Authors | Anderson, E., Stavenhagen, K., Kolarich, D., Sommerhoff, C. P., Maurer, M. and Metz, M. |
Citation | Anderson, E., Stavenhagen, K., Kolarich, D., Sommerhoff, C. P., Maurer, M. and Metz, M.: Human mast cell tryptase is a potential treatment for snakebite envenoming across multiple snake species. Front. Immunol. 2018: 9; 1532. |
Corresponding authors | Metz, M. |
DocNum | o.321 |
DocType | |
Edition; Page | 9; 1532 |
IF | 4.72 |
Publisher | Front. Immunol. |
ReleaseDate | 2018 |
Snake envenoming is a serious and neglected public health crisis that is responsible for as many as 125,000 deaths per year, which is one of the reasons the World Health Organization has recently reinstated snakebite envenoming to its list of category A neglected tropical diseases. Here, we investigated the ability of human mast cell prote- ases to detoxify six venoms from a spectrum of phylogenetically distinct snakes. To this end, we developed a zebra sh model to assess effects on the toxicity of the venoms and characterized the degradation of venom proteins by mass spectrometry. All snake venoms tested were detoxi ed by degradation of various venom proteins by the mast cell protease tryptase β, and not by other proteases. Our data show that recombinant human tryptase β degrades and detoxi es a phylogenetically wide range of venoms, indicating that recombinant human tryptase could possibly be developed as a universal antidote to venomous snakebites.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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