Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
Use: Start with an overview of all publications. Use tag links to list selected documents or to list an entire category, e.g. Original Work, Books, Book Chapters, Reviews. If you know what you are looking for, enter this term in the search field.
Immunoglobulin E-mediated autoimmunity
Filename | 134. Maurer et al., IgE-mediated autoimm.,FrontImm 2018.pdf |
Filesize | 259.29 KB |
Version | r.134 |
Date added | June 17, 2020 |
Downloaded | 2 times |
Category | Reviews |
Tags | autoallergy, bullous pemphigoid, immunoglobulin e-mechanisms, immunoglobulin e-mediated autoimmunity, urticaria |
Authors | Maurer, M., Altrichter, S., Schmetzer, O., Scheffel, J., Church, M. K., and Metz, M. |
Citation | Maurer, M., Altrichter, S., Schmetzer, O., Scheffel, J., Church, M. K., and Metz, M.: Immunoglobulin E-mediated autoimmunity. Front. Immunol. 2018: 9; 689. |
Corresponding authors | Church, M. K. |
DocNum | r.134 |
DocType | |
Edition; Page | 9; 689 |
IF | 4.72 |
Publisher | Front. Immunol. |
ReleaseDate | 2018 |
The study of autoimmunity mediated by immunoglobulin E (IgE) autoantibodies, which may be termed autoallergy, is in its infancy. It is now recognized that systemic lupus erythematosus, bullous pemphigoid (BP), and chronic urticaria, both spontaneous and inducible, are most likely to be mediated, at least in part, by IgE autoantibodies. The situation in other conditions, such as autoimmune uveitis, rheumatoid arthritis, hyper- thyroid Graves’ disease, autoimmune pancreatitis, and even asthma, is far less clear but evidence for autoallergy is accumulating. To be certain of an autoallergic mechanism, it is necessary to identify both IgE autoantibodies and their targets as has been done with the transmembrane protein BP180 and the intracellular protein BP230 in BP and IL-24 in chronic spontaneous urticaria. Also, IgE-targeted therapies, such as anti-IgE, must have been shown to be of benefit to patients as has been done with both of these conditions. This comprehensive review of the literature on IgE-mediated autoallergy focuses on three related questions. What do we know about the prevalence of IgE autoantibodies and their targets in different diseases? What do we know about the relevance of IgE autoantibodies in different diseases? What do we know about the cellular and molecular effects of IgE autoantibodies? In addition to providing answers to these questions, based on a broad review of the literature, we outline the current gaps of knowledge in our understanding of IgE autoantibodies and describe approaches to address them.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
Download-Information
To be able to download the offered contents, you have to login. If you do not know the login, please write me your request.