Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Impact of lanadelumab on health-related quality of life in patients with hereditary angioedema in the HELP study

Filename 426. Lumry et al., Impact of Lana QoL HAE HELP study,Allergy2021.pdf
Filesize 711 KB
Version o.426
Date added June 1, 2021
Downloaded 1 time
Category Original Work
Tags AE-QoL, Hereditary Angioedema, Lanadelumab, long-term prophylaxis, Quality of life
Authors Lumry, W. R., Weller, K., Magerl, M., Banerji, A., Longhurst, H. J., Riedl, M. A., Lewis, H. B., Lu, P., Devercelli, G., Jain, G., and Maurer, M.
Citation Lumry, W. R., Weller, K., Magerl, M., Banerji, A., Longhurst, H. J., Riedl, M. A., Lewis, H. B., Lu, P., Devercelli, G., Jain, G., and Maurer, M.: Impact of lanadelumab on health-related quality of life in patients with hereditary angioedema in the HELP study. Allergy 2021: 76; 1188-1198.
Corresponding authors Lumry, W. R.
DocNum o.426
DocType PDF
IF TBD (IF 2020: 13.15)
Publisher Allergy
ReleaseDate 2021

Background: An objective of the phase 3 HELP Study was to investigate the effect of lanadelumab on health-related quality of life (HRQoL) in patients with hereditary angioedema (HAE).

Methods: Patients with HAE-1/2 received either lanadelumab 150 mg every 4 weeks (q4wks; n = 28), 300 mg q4wks (n = 29), 300 mg every 2 weeks (q2wks; n = 27), or pla-cebo (n = 41) for 26 weeks (days 0–182). The Angioedema Quality of Life Questionnaire (AE-QoL) was administered monthly, consisting of four domain (functioning, fatigue/mood, fears/shame, nutrition) and total scores. The generic EQ-5D-5L questionnaire was administered on days 0, 98, and 182. Comparisons were made between placebo and (a) all lanadelumab-treated patients and (b) individual lanadelumab groups for changes in scores (day 0–182) and proportions achieving the minimal clinically impor-tant difference (MCID, −6) in AE-QoL total score.

Results: Compared with the placebo group, the lanadelumab total group demon-strated significantly greater improvements in AE-QoL total and domain scores (mean change, −13.0 to −29.3; p < 0.05 for all); the largest improvement was in functioning. A significantly greater proportion of the lanadelumab total group achieved the MCID (70% vs 37%; p= 0.001). The lanadelumab 300 mg q2wks group had the highest pro-portion (81%; p = 0.001) and was 7.2 times more likely to achieve the MCID than the placebo group. Mean EQ-5D-5L scores at day 0 were high in all groups, indicating low impairment, with no significant changes at day 182.

Conclusion: Patients with HAE-1/2 experienced significant and clinically meaningful improvements in HRQoL measured by AE-QoL following lanadelumab treatment in the HELP Study.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429