Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Inflammatory Murine Skin Responses to UV-B Light Are Partially Dependent on Endothelin-1 and Mast Cells
Filename | 49. Metz et al., Infl. murine skin& UVB,Am.J.Path.2006.pdf |
Filesize | 457.76 KB |
Version | o.049 |
Date added | May 25, 2020 |
Downloaded | 0 times |
Category | Original Work |
Authors | Metz, M., Lammel, V., Gibbs, B.F., and Maurer, M. |
Citation | Metz, M., Lammel, V., Gibbs, B.F., and Maurer, M.: Inflammatory murine skin responses to UV-B light are partially dependent on Endothelin-1 and mast cells. Am. J. Pathol. 2006: 169; 815-822. IF: 5.92 |
Corresponding authors | Metz, M. |
DocNum | O.49 |
DocType | |
Edition; Page | 169; 815-822 |
IF | 5.92 |
Publisher | Am. J. Pathol |
ReleaseDate | 2006 |
Endothelin (ET-1) has been shown to crucially contribute to UV-induced skin responses such as tanning. To test whether ET-1 is also involved in early cutaneous reactions to UV, we assessed ET-1 skin levels in UV-irradiated mice. In correlation with the levels of UV-induced skin inflammation, ET-1 concentrations increased substantially and continually. Moreover, blocking of ET-1 receptors (ETA) resulted in significantly decreased cutaneous inflammation following UV irradiation. When we assessed skin responses to ET-1 injections, we observed prominent mast cell degranulation and mast cell-dependent inflammation. Since mast cells also critically contributed to UV-induced inflammation, we determined the ET-1-dependent inflammatory response to UV in the absence and presence of these cells. Interestingly, ETA blockade did not decrease UV-induced inflammation in mast cell-deficient mice, unless these mice had been adoptively transferred with mast cells before irradiation. This indicates that skin inflammation due to UV irradiation is caused in part by ET-1 acting on skin mast cells.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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