Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Learnings from real-life experience of using omalizumab for chronic urticaria in Latin America

Filename 347. Cherrez et al., Learnings Oma CU Latin America, WAO J 2019.pdf
Filesize 997 KB
Version o.347
Date added June 9, 2020
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Category Original Work
Tags chronic spontaneous urticaria, Latin America, omalizumab, Patient-reported outcomes, Quality of life
Authors Cherrez-Ojeda, I., Maurer, M., Bernstein, J. A., Vanegas, E., Felix, M., Ramon, G. D., Ensina, L. F., Larco Sousa, J. I., Matos Benavides, E. E., Cardona Villa, R., Latour Staffeld, P., Morfin-Maciel, B. M., Mori, J., Wilches, P. C.; Mata, V. L., and Cherrez, A.
Citation Cherrez-Ojeda, I., Maurer, M., Bernstein, J. A., Vanegas, E., Felix, M., Ramon, G. D., Ensina, L. F., Larco Sousa, J. I., Matos Benavides, E. E., Cardona Villa, R., Latour Staffeld, P., Morfin-Maciel, B. M., Mori, J., Wilches, P. C.; Mata, V. L., and Cherrez, A.: Learnings from real-life experience of using omalizumab for chronic urticaria in Latin America. WAO Journal 2019: 12; 100011.
Corresponding authors Cherrez-Ojeda, I.
DocNum O.347
DocType PDF
Edition; Page 12; 100011
IF TBD (IF 2018: 3.68)
Publisher WAO Journal
ReleaseDate 2019

Background: Updated urticaria guidelines recommend that patients should be assessed for disease activity, severity, control, and quality of life at baseline and follow up. Regarding treatment, guidelines consider second generation antihistamines as the cornerstone in therapy for chronic urticaria (CU), while other drugs, such as omalizumab, are conceived as second-line alternatives. In regards to omalizumab, despite advances in the management of CU, there are still open questions about timing, dosing, and objective measures for clinical response. This study was designed to portray the use of patient-reported outcomes (PROs) in chronic urticaria management, as well as the effectiveness and treatment patterns of omalizumab in CU, as seen in a real-life setting in Latin America.

Methods: This is a retrospective observational study, involving 72 Latin American patients with chronic urticaria treated with omalizumab. Patient reported outcomes and treatment patterns, response, quality of life improvement and discontinuation were analyzed.

Results: From the 72 patients, 91.7% (n ¼ 66) were assessed through PROs, where urticaria control test (UCT) was the most used (79.2%; n ¼ 57). Overall, 80.0% (n ¼ 44) responded to omalizumab at some point of the treatment. Omalizumab 300 mg was associated with earlier response compared to lower doses. Regardless of dosage, most patients assessed with CU-Q2oL improved quality of life (80.8%; n ¼ 21). With respect to omalizumab discontinuation, 20.8% (n ¼ 15) patients interrupted omalizumab before the 3rd month of treatment (p ¼ .000).

(Last update: 11.2020)

Number of publications (original work and reviews) in peer-reviewed journals: 582
Number of original publications in peer-reviewed journals: 418
Number of reviews in peer-reviewed journals: 164
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3203,30
Cumulative IF for original publications in peer-reviewed journals: 2563,44
Cumulative IF for reviews in peer-reviewed journals: 639,86
Citations, Hirsch index: (view on Google Scholar) 43911, 103