Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Lower IgA levels in chronic spontaneous urticaria are associated with lower IgE levels and autoimmunity

Filename 424. Sauer et al., IgA levels CSU and IgE...,FrontImmunol 2021.pdf
Filesize 1.22 MB
Version o.424
Date added June 1, 2021
Downloaded 1 time
Category Original Work
Tags autoimmunedisease, autoreactivity, basophils, chronic spontaneous urticaria, eosinophils, immunoglobulin A, immunoglobulin E
Authors Sauer, M., Scheffel, J., Frischbutter, S., Kolkhir, P., Xiang, Y.-K., Siebenhaar, F., Altrichter, S., Maurer, M., Metz, M., and Krause, K.
Citation Sauer, M., Scheffel, J., Frischbutter, S., Kolkhir, P., Xiang, Y.-K., Siebenhaar, F., Altrichter, S., Maurer, M., Metz, M., and Krause, K.: Lower IgA levels in chronic spontaneous urticaria are associated with lower IgE levels and autoimmunity. Front. Immunol. 2021: 12; 657211.
Corresponding authors Krause, K.
DocNum o.424
DocType PDF
IF 8.79
Publisher Front. Immunol.
ReleaseDate 2021

Background: The pathogenesis of chronic spontaneous urticaria (CSU) is stillinsufficiently understood. Recentfindings suggest that immunoglobulins, in particularIgE but also IgA, play a role in the development of CSU.

Objective: Our aim was to assess differences in clinical and laboratory markers betweenCSU patients with and without lower levels of serum IgA and IgE.

Methods: We analyzed the data of 606 patients with CSU by dividing them into fourgroups based on their IgA and IgE levels. The groups were compared for their spectrum ofsymptoms, disease activity, concomitant autoimmunity and routine laboratory markers.Autoreactivity was assessed by basophil activation test (BAT). Moreover, IgE-anti-thyroidperoxidase (TPO) was measured.

Results:Of the patients with lower IgE levels, 66.5% also had lower IgA levels (r=0.316,p<0.001). Patients with lower IgA and lower IgE levels showed a higher prevalence ofrecurrent angioedema (p=0.03, p=0.04) and concomitant autoimmunity (p=0.006,p<0.001). Autoreactivity was also found more frequently in patients with lower IgA andlower IgE levels (p=0.003, p<0.001). Reduced basophil counts were linked to both, lowerIgA and lower IgE levels (p<0.001), whereas low eosinophil counts were primarily presentin patients with lower IgE levels (p=0.04, p<0.001). Patients with elevated IgE-anti-TPOlevels had lower IgA (p=0.007) and IgE levels (p=0.001).

Conclusion: Lower IgA levels in CSU are linked to lower IgE levels and features ofautoimmune urticaria. Ourfindings encourage to screen CSU patients for serum IgA andIgE levels and to further assess their role as disease biomarkers.

 

(Last update: 12.2023)

Number of original publications in peer-reviewed journals:580
Number of reviews in peer-reviewed journals:210
Number of publications (original work and reviews) in peer-reviewed journals:790
Cumulative IF for original publications in peer-reviewed journals:4196.39
Cumulative IF for reviews in peer-reviewed journals:1409.32
Cumulative IF of publications (original work & reviews) in peer-reviewed journals:5605.71
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023)36836

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