Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Mas-related G protein-coupled receptor X2 and its activators in dermatologic allergies

Filename 164. Kühn et al., MRGPRX2 and its activators, JACI 2021.pdf
Filesize 963.12 KB
Version r.164
Date added March 15, 2021
Downloaded 503 times
Category Reviews
Tags agonists, antimicrobial peptides, atopic dermatitis, chronic spontaneous urticaria, eosinophil granule proteins, itch, MRGPRX2, MRGX2, neuropeptides, Pruritus, substance P
Authors Kühn, H., Kolkhir, P., Babina, M., Düll, M., Frischbutter, S., Fok, J. S., Jiao, Q., Metz, M., Scheffel, J., Wolf, K., Kremer, A. E., and Maurer, M.
Citation Kühn, H., Kolkhir, P., Babina, M., Düll, M., Frischbutter, S., Fok, J. S., Jiao, Q., Metz, M., Scheffel, J., Wolf, K., Kremer, A. E., and Maurer, M.: Mas-related G protein-coupled receptor X2 and its activators in dermatologic allergies. J. Allergy Clin. Immunol. 2021: 147; 456-469.
Corresponding authors Maurer, M.
DocNum r.164
DocType PDF
IF 14.29
Publisher J. Allergy Clin. Immunol.
ReleaseDate 2021

The Mas-related G protein–coupled receptor X2 (MRGPRX2) is a multiligand receptor responding to various exogenous and endogenous stimuli. Being highly expressed on skin mast cells, MRGPRX2 triggers their degranulation and release of proinflammatory mediators, and it promotes multicellular signaling cascades, such as itch induction and transmission in sensory neurons. The expression of MRGPRX2 by skin mast
cells and the levels of the MRGPRX2 agonists (eg, substance P, major basic protein, eosinophil peroxidase) are upregulated in the serum and/or skin of patients with inflammatory and pruritic skin diseases, such as chronic spontaneous urticaria or atopic dermatitis. Therefore, MRGPRX2 and its agonists might be potential biomarkers for the progression of cutaneous inflammatory diseases and the response to treatment. In
addition, they may represent promising targets for prevention and treatment of signs and symptoms in patients with skin diseases or drug reactions. To assess this possibility, this review explores the role and relevance of MRGPRX2 and its activators in cutaneous inflammatory disorders and chronic pruritus. (J Allergy Clin Immunol 2021;147:456-69.)

 

(Last update: 12.2023)

Number of original publications in peer-reviewed journals:580
Number of reviews in peer-reviewed journals:210
Number of publications (original work and reviews) in peer-reviewed journals:790
Cumulative IF for original publications in peer-reviewed journals:4196.39
Cumulative IF for reviews in peer-reviewed journals:1409.32
Cumulative IF of publications (original work & reviews) in peer-reviewed journals:5605.71
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023)36836

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