Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
Use: Start with an overview of all publications. Use tag links to list selected documents or to list an entire category, e.g. Original Work, Books, Book Chapters, Reviews. If you know what you are looking for, enter this term in the search field.
Mast cells determine the magnitude of bacterial toxin-induced skin inflammation
Filename | 75. Metz et al,MC determine the magnitude of bactial,Exp Derm 2009.pdf |
Filesize | 322.44 KB |
Version | o.075 |
Date added | May 27, 2020 |
Downloaded | 0 times |
Category | Original Work |
Authors | Metz, M., Magerl, M., Kühl, N. F., Valeva, A., Bhakdi, S., and Maurer, M. |
Citation | Metz, M., Magerl, M., Kühl, N. F., Valeva, A., Bhakdi, S., and Maurer, M.: Mast cells determine the magnitude of bacterial toxin-induced skin inflammation. Exp. Dermatol. 2009: 18; 160-166. IF: 3.24 |
Corresponding authors | Maurer, M. |
DocNum | o.075 |
DocType | |
Edition; Page | 18; 160-166 |
IF | 3.24 |
Publisher | Exp. Dermatol. |
ReleaseDate | 2009 |
Mast cells are known to be important effector cells in innate immune responses to bacterial infections. However, up to now, neither the mechanisms nor the relevance of mast cell degranulation in innate skin immune responses to bacteria have been adequately addressed. In this article, we show that the bacterial toxins streptolysin O (SLO) and a-toxin potently induce degranulation of mast cells in vitro and in vivo. Furthermore, intradermal injection of the toxins results in pronounced skin inflammation, which either resolves quickly within a few h (SLOinduced inflammation) or presents a chronic process with ongoing inflammation for weeks (a-toxin). Interestingly, mast cells mediated the inflammatory effects of SLO, but in contrast limited inflammatory skin responses to a-toxin. These findings further support the hypothesis that mast cells are critically involved in initiating and modulating optimal host responses to bacteria by either inflammatory or anti-inflammatory effects, depending on the course of the host reaction induced by the pathogen.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
Download-Information
To be able to download the offered contents, you have to login. If you do not know the login, please write me your request.