Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Mast cells drive IgE-mediated disease but might be bystanders in many other inflammatory and neoplastic conditions

Filename 146. Maurer et al., Mc drive IgE-mediated, JACI 2019.pdf
Filesize 420 KB
Version r.146
Date added June 17, 2019
Downloaded 1 time
Category Reviews
Tags Inflammation, mast cells, pathogenesis
Authors Maurer, M., Taube, C., Schröder, N. W. J., Ebmeyer, J., Siebenhaar, F., Geldmacher, A., Schubert, N., and Roers, A.
Citation Maurer, M., Taube, C., Schröder, N. W. J., Ebmeyer, J., Siebenhaar, F., Geldmacher, A., Schubert, N., and Roers, A.+: Mast cells drive IgE-mediated disease but might be bystanders in many other inflammatory and neoplastic conditions. J. Allergy Clin. Immunol. 2019: 4; S19-30.
Corresponding authors Maurer, M. and Roers, A.
DocNum r.146
DocType PDF
Edition; Page 4; S19-30
IF 10.23
Publisher J. Allergy Clin. Immunol.
ReleaseDate 2019

Mast cells (MCs) are capable of executing powerful inflammatory response programs triggered by surface IgE cross-linking or through pattern recognition receptors. The question of how MCs contribute to human disease has been intensely investigated and stimulated much controversy. Correlative evidence comes from human studies, pointing to pathogenetic or protective MC functions in patients with atopic conditions, autoimmune disorders, type 2 diabetes, chronic urticaria, mastocytosis, and cancer. Experiments in MC-deficient mice underpinned key roles for MCs in patients with IgE-mediated allergic conditions. Important pathogenetic MC contributions to other inflammatory and neoplastic conditions were suggested by studies in traditional KIT mutant MC-deficient mouse strains. However, many of these findings were not reproduced in more recently developed improved mouse models of MC deficiency, largely ruling out roles for MCs in mouse models for autoimmune disease, diabetes, and cancer. We discuss limitations of studies in mice and human subjects and provide suggestions for how they can be overcome, such as through the development of specific and selective MC-targeted treatments. (J Allergy Clin Immunol 2019;144:S19-30.)

(Last update: 02.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 601
Number of original publications in peer-reviewed journals: 432
Number of reviews in peer-reviewed journals: 169
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3326,21
Cumulative IF for original publications in peer-reviewed journals: 2659,47
Cumulative IF for reviews in peer-reviewed journals: 666,74
Citations, Hirsch index: (view on Web of Science) 24104