Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Mast cells in endometriosis: Guilty or innocent bystanders?
|Filename||59. Kirchhoff et al_Mast cells in EMS _EOTT_2012.pdf|
|Date added||June 26, 2020|
|Tags||endometriosis, Inflammation, mast cell, pain|
|Authors||Kirchhoff, D., Kaulfuss, S., Maurer, M., and Zollner, T. M.|
|Citation||Kirchhoff, D., Kaulfuss, S., Maurer, M., and Zollner, T. M.: Mast cells in endometriosis: Guilty or innocent bystanders? Expert Opin. Ther. Targets 2012: 16; 237-241.|
|Corresponding authors||Kirchhoff, D.|
|Edition; Page||16; 237-241|
|Publisher||Expert Opin. Ther. Targets|
Endometriosis (EMS) is a chronic, estrogen-dependent inflammatory disease characterized by growth of endometrial tissue outside the uterine cavity. Symptoms in EMS patients include severe pelvic pain, dysmenorrhea, dyspar- eunia and infertility. To date, medical therapies are mostly based on hor- monal suppressive drugs that induce a hypoestrogenic state. Although being effective regarding the reduction of endometriotic tissue masses and pelvic pain, this treatment is accompanied by severe side effects. Since EMS is associated with chronic inflammation, novel therapeutic strategies also focus on immune modulating drugs. However, little is known about how and to what extent immune cell subsets contribute to the network of locally produced cytokines, chemokines and other mitogenic factors that modulate the growth of ectopic endometrial implants and the inflammation associated with them. Mast cells (MCs) are known to be key players of the immune sys- tem, especially during allergic reactions. However, in recent years MCs have been identified to exhibit a far broader range of functions and to be involved in host defense and wound healing responses. Here, recent reports that imply an involvement of MCs in EMS has been reviewed, while the value of novel mouse models for clarifying their contribution to the pathology of this condition has been discussed.
(Last update: 08.2021)
|Number of publications (original work and reviews) in peer-reviewed journals:||636|
|Number of original publications in peer-reviewed journals:||462|
|Number of reviews in peer-reviewed journals:||174|
|Cumulative IF of publications (original work & reviews) in peer-reviewed journals:||3834,12|
|Cumulative IF for original publications in peer-reviewed journals:||3043,14|
|Cumulative IF for reviews in peer-reviewed journals:||790,98|
|Citations, Hirsch index: (view on Web of Science)||26429|