Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4

Filename 175. Nelissen et al., MC protect spinal cord damage NEUROBIOLOGY 2013.pdf
Filesize 2 MB
Version o.175
Date added June 6, 2020
Downloaded 0 times
Category Original Work
Tags IL-10, IL-13, IL-6, Inflammation, mast cell, MCP-1, mMCP4, Spinal cord injury, TNF-α
Authors Nelissen, S., Vangansewinkel, T., Geurts, N., Geboes, L., Lemmens, E., Vidal, P. M., Lemmens, S., Willems, L., Boato, F., Dooley, D., Pehl, D., Pejler, G., Maurer, M. Metz, M., and Hendrix, S.
Citation Nelissen, S., Vangansewinkel, T., Geurts, N., Geboes, L., Lemmens, E., Vidal, P. M., Lemmens, S., Willems, L., Boato, F., Dooley, D., Pehl, D., Pejler, G., Maurer, M. Metz, M., and Hendrix, S.: Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4. Neurobiol. Dis. 2013: 62C; 260-272.
Corresponding authors Hendrix, S.
DocNum O.175
DocType PDF
Edition; Page 62C; 260-272
IF 5.20
Publisher Neurobiol. Dis.
ReleaseDate 2013

Mast cells (MCs) are found abundantly in the central nervous system and play a complex role in neuroinflammatory diseases such as multiple sclerosis and stroke. In the present study, we show that MC-deficient KitW-sh/W-sh mice dis- play significantly increased astrogliosis and T cell infiltration as well as significantly reduced functional recovery after spinal cord injury compared to wildtype mice. In addition, MC-deficient mice show significantly increased levels of MCP-1, TNF-α, IL-10 and IL-13 protein levels in the spinal cord. Mice deficient in mouse mast cell protease 4 (mMCP4), an MC-specific chymase, also showed increased MCP-1, IL-6 and IL-13 protein levels in spinal cord samples and a decreased functional outcome after spinal cord injury. A degradation assay using supernatant from MCs derived from either mMCP4−/− mice or controls revealed that mMCP4 cleaves MCP-1, IL-6, and IL-13 suggest- ing a protective role for MC proteases in neuroinflammation. These data show for the first time that MCs may be protective after spinal cord injury and that they may reduce CNS damage by degrading inflammation-associated cytokines via the MC-specific chymase mMCP4

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429