Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Mast cells protect from skin tumor development and limit tumor growth during cutaneous de novo carcinogenesis in a Kit-dependent mouse model

Filename 193. Siebenhaar et alMast cell protect Exp Derm 2014.pdf
Filesize 377 KB
Version o.193
Date added June 6, 2020
Downloaded 0 times
Category Original Work
Tags carcinogenesis, Inflammation, mast cells
Authors Siebenhaar, F., Metz, M., and Maurer, M.
Citation Siebenhaar, F., Metz, M., and Maurer, M.: Mast cells protect from skin tumor development and limit tumor growth during cutaneous de novo carcinogenesis in a Kit-dependent mouse model. Exp. Dermatol. 2014: 23; 159-164.
Corresponding authors Siebenhaar, F.
DocNum O.193
DocType PDF
Edition; Page 23; 159-164
IF 3.76
Publisher Exp. Dermatol.
ReleaseDate 2014

Epidermal tumors belong to the most frequent type of neoplasms, and tumor-associated accumulation of mast cells (MCs) has first been observed more than a century ago. Therefore, MCs have been implicated in tumor development and growth; however, the results regarding the role of MC in cutaneous de novo carcinogenesis are still controversially discussed. Here, we subjected MC-deficient KitW/KitW v mice to chemical skin carcinogenesis. Tumors were induced using the carcinogen 7,12-dimethylbenz[a]-anthracene and subsequent treatment with the tumor promoter 12-tetradecanoyl-phorbol-13- acetat. The treatment resulted in pronounced inflammatory cell infiltrates that were diminished in MC-deficient animals. Unexpectedly, tumor development and growth was significantly increased in MC-deficient KitW/KitW v mice. The repair of their MC deficiency by local adoptive transfer of MCs normalized tumor incidence and growth. The recruitment of skin-infiltrating immune cells, particularly of F4/80+ monocytes, Gr-1+ granulocytes, B220+ B cells and CD8+ T lymphocytes, to sites of tumor development was, in part, also controlled by MCs. Recent evidence indicated the importance of local antitumor tissue immunity which prevents tumor development. These findings suggest a critical role for MCs in mediating these host antitumor immune responses in the skin.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429