Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Microbiota-dependent and –independent effects of dietary fiber on human health

Filename 155. Cai et al., Microbiota dietary fiber, BJP 2020.pdf
Filesize 2 MB
Version r.155
Date added June 17, 2020
Downloaded 1 time
Category Reviews
Authors Cai, Y., Folkerts, J., Folkerts, G., Maurer, M., and Braber, S.
Citation Cai, Y., Folkerts, J., Folkerts, G., Maurer, M., and Braber, S.: Microbiota-dependent and –independent effects of dietary fiber on human health. Brit. J. Pharmacol. 2020: 177; 1363-1381.
Corresponding authors Braber, S.
DocNum r.155
DocType PDF
Edition; Page 177; 1363-1381
IF IF 2019: 7.73
Publisher Brit. J. Pharmacol
ReleaseDate 2020

Dietary fibre, such as indigestible oligosaccharides and polysaccharides, occurs in many foods and has gained considerable importance related to its beneficial effects on host health and specific diseases. Dietary fibre is neither digested nor absorbed in the small intestine and modulates the composition of the gut microbiota. New evidence indicates that dietary fibre also interacts directly with the epithelium and immune cells throughout the gastrointestinal tract by microbiota‐independent effects. This review focuses on how dietary fibre improves human health and the reported health benefits that are connected to molecular pathways, in (a) a microbiota‐independent manner, via interaction with specific surface receptors on epithelial and immune cells regulating intestinal barrier and immune function, and (b) a microbiota‐dependent manner via maintaining intestinal homeostasis by promoting beneficial microbes, including Bifidobacteria and Lactobacilli, limiting the growth, adhesion, and cytotoxicity of pathogenic microbes, as well as stimulating fibre‐derived microbial short‐chain fatty acid production.

(Last update: 02.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 601
Number of original publications in peer-reviewed journals: 432
Number of reviews in peer-reviewed journals: 169
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3326,21
Cumulative IF for original publications in peer-reviewed journals: 2659,47
Cumulative IF for reviews in peer-reviewed journals: 666,74
Citations, Hirsch index: (view on Web of Science) 24104