Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Platelet-activating factor (PAF) induces wheal and flare skin reactions independent of mast cell degranulation
| Filename | 149. Krause et al PAF induces wheal.Allergy.2013.pdf |
| Filesize | 210.99 KB |
| Version | o.149 |
| Date added | June 4, 2020 |
| Downloaded | 0 times |
| Category | Original Work |
| Tags | histamine, microdialysis, platelet-activating factor, prostaglandin D2, wheal and flare |
| Authors | Krause, K., Giménez-Arnau, A., Martinez-Escala, E., Farré-Albadelejo, M., Abajian, M., Church, M. K., and Maurer, M. |
| Citation | Krause, K., Giménez-Arnau, A., Martinez-Escala, E., Farré-Albadelejo, M., Abajian, M., Church, M. K., and Maurer, M.: Platelet-activating factor (PAF) induces wheal and flare skin reactions independent of mast cell degranulation. Allergy 2013: 68; 256-258. |
| Corresponding authors | M. K. |
| DocNum | O.149 |
| DocType | |
| Edition; Page | 68; 256-258. |
| IF | 5.99 |
| Publisher | Allergy |
| ReleaseDate | 2013 |
Background: Platelet-activating factor (PAF) causes wheal and flare responses which are abrogated by H1-antihistamines giving rise to the hypothesis that PAF- induced wheal development is secondary to histamine release from dermal mast cells. But is this hypothesis correct?
Methods: Wheal and flare responses were induced by intradermal injection of PAF, codeine and histamine in 14 healthy volunteers. Dermal histamine and PGD2 contractions were measured using microdialysis.
Results: PAF, unlike histamine and codeine, did not cause a statistically signifi- cant rise in mean histamine levels with ten persons showing negligible histamine release. Codeine caused a significant but variable histamine release, ranging from 29 to 282 ng/ml. Codeine, but not PAF or histamine, caused a small but statisti- cally significant release of PGD2.
Conclusion: Wheal and flare reactions in human skin induced by PAF are not associated with histamine release and, therefore, appear to be independent of mast cell degranulation.
(Last update: 12.2023)
| Number of original publications in peer-reviewed journals: | 580 |
| Number of reviews in peer-reviewed journals: | 210 |
| Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
| Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
| Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
| Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
| Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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