Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Rolle der Mastzelle bei allergischem Asthma bronchiale
Filename | 23. Taube Maurer.Role of MC allerg.asthma,AllergoJ.2008.pdf |
Filesize | 93.00 KB |
Version | r.023 |
Date added | June 21, 2020 |
Downloaded | 0 times |
Category | Reviews |
Authors | Taube, C. and Maurer, M. |
Citation | Taube, C. and Maurer, M.: Role of mast cells in the development of allergic asthma. Allergo J. 2008: 17; 297-300. |
Corresponding authors | Taube, C. |
DocNum | R.23 |
DocType | |
Edition; Page | 17; 297-300 |
IF | N/A |
Publisher | Allergo J. |
ReleaseDate | 2008 |
Mast cells have been recognized for a long time as mere effector cells in allergic reactions. New studies suggest that mast cells are not only involved in anaphylactic reactions, but also during the development and maintenance of allergic inflammation. Indeed, studies in models of allergic asthma demonstrate a pivotal role of mast cells in the development of airway inflammation and bronchial hyperreactivity. Especially mediators produced by mast cells, like histamine and tumor necrosis factor, are involved in this process.
Mastzellen sind seit Jahrzehnten als „Allergieeffektorzellen“ im Rahmen akuter allergischer Reaktionen beschrieben. Neuere Daten belegen nun, dass Mastzellen nicht nur an der Auslösung anaphylaktischer Reaktionen beteiligt sind, sondern auch maßgeblich für die Entstehung und Unterhaltung allergischer Entzündungsreaktionen sind. Insbesondere Untersuchungen an Modellen des allergischen Asthmas belegen eine zentrale Rolle von Mastzellen bei der initialen Entwicklung einer Atemwegsentzündung und bronchialen Überempfindlichkeit. Dies scheint durch Mastzellmediatoren, wie Histamin und Tumor-Nekrose-Faktor, vermittelt zu werden.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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