Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself
| Filename | 429. Ferreira-Gomes et al., TGF-beta, Nat Comm 2021.pdf |
| Filesize | 6.44 MB |
| Version | o.429 |
| Date added | June 1, 2021 |
| Downloaded | 0 times |
| Category | Original Work |
| Tags | chronic immune response, Covid-19, SARS-CoV-2 |
| Authors | Ferreira-Gomes, M., Kruglov, A., Durek, P., Heinrich, F., Tizian, C., Heinz, G. A., Pascual-Reguant, A., Du, W., Mothes, R., Fan, C., Frischbutter, S., Habenicht, K., Budzinski, L., Ninnemann, J., Jani, P. K., Guerra, G., Lehmann, K., Matz, M., Ostendorf, L., Heiberger, L., Chang, H.-D., Bauherr, S., Maurer, M., Schönrich, G., Raftery, M., Kallinich, T., Mall, M. A., Angermair, S., Treskatsch, S., Dörner, T., Corman, V. M., Diefenbach, A., Volk, H.-D., Elezkurtaj, S., Winkler, T. H., Dong, J., Hauser, A. E., Radbruch, H., Witkowski, M., Melchers, F., Radbruch, A., and Mashreghi, M.-F. |
| Citation | Ferreira-Gomes, M., Kruglov, A., Durek, P., Heinrich, F., Tizian, C., Heinz, G. A., Pascual-Reguant, A., Du, W., Mothes, R., Fan, C., Frischbutter, S., Habenicht, K., Budzinski, L., Ninnemann, J., Jani, P. K., Guerra, G., Lehmann, K., Matz, M., Ostendorf, L., Heiberger, L., Chang, H.-D., Bauherr, S., Maurer, M., Schönrich, G., Raftery, M., Kallinich, T., Mall, M. A., Angermair, S., Treskatsch, S., Dörner, T., Corman, V. M., Diefenbach, A., Volk, H.-D., Elezkurtaj, S., Winkler, T. H., Dong, J., Hauser, A. E., Radbruch, H., Witkowski, M., Melchers, F., Radbruch, A., and Mashreghi, M.-F.: SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself. Nat. Commun. 2021: 12; 1961. |
| Corresponding authors | Mashreghi, M.-F. |
| DocNum | o.429 |
| DocType | |
| Equivalent authors | Ferreira-Gomes, M., Kruglov, A., Durek, P., Heinrich, F., Tizian, C., Heinz, G. A., Radbruch, H., Witkowski, M., Melchers, F., Radbruch, A., and Mashreghi, M.-F. |
| IF | 17.69 |
| Publisher | Nat. Commun. |
| ReleaseDate | 2021 |
The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2. Here we analyze, at the single cell level, plasmablasts egressed into the blood to study thedynamics of adaptive immune response in COVID-19 patients requiring intensive care. Beforeseroconversion in response to SARS-CoV-2 spike protein, peripheral plasmablasts display atype 1 interferon-induced gene expression signature; however, following seroconversion,plasmablasts lose this signature, express instead gene signatures induced by IL-21 and TGF-β,and produce mostly IgG1 and IgA1. In the sustained immune reaction from COVID-19patients, plasmablasts shift to the expression of IgA2, thereby reflecting an instruction byTGF-β. Despite their continued presence in the blood, plasmablasts are not found in the lungsof deceased COVID-19 patients, nor does patient IgA2 binds to the dominant antigens ofSARS-CoV-2. Our results thus suggest that, in severe COVID-19, SARS-CoV-2 triggers achronic immune reaction that is instructed by TGF-β, and is distracted from itself.
(Last update: 12.2023)
| Number of original publications in peer-reviewed journals: | 580 |
| Number of reviews in peer-reviewed journals: | 210 |
| Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
| Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
| Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
| Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
| Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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