Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Similar Efficacy with Omalizumab in Chronic Idiopathic/Spontaneous Urticaria Despite Different Background Therapy

Filename 211. Casale et al., Similar eff. omalizumab ciu csu, JACI Pract. 2015.pdf
Filesize 551 KB
Version o.211
Date added July 29, 2020
Downloaded 0 times
Category Original Work
Tags Antihistamine, Chronic idiopathic, Chronic spontaneous, hive, itch, omalizumab, Pruritus, urticaria, wheal
Authors Casale, T. B., Bernstein, J. A., Maurer, M. Saini, S. S., Trzaskoma, B., Chen, H., Grattan, C., Gimenèz-Arnau, A., Kaplan, A. P., and Rosén, K.
Citation Casale, T. B., Bernstein, J. A., Maurer, M. Saini, S. S., Trzaskoma, B., Chen, H., Grattan, C., Gimenèz-Arnau, A., Kaplan, A. P., and Rosén, K.: Similar efficacy with Omalizumab in chronic idiopathic/spontaneous urticaria despite different background therapy. J. Allergy Clin. Immunol. Pract. 2015: 3; 743-750.
Corresponding authors Rosén, K.
DocNum O.211
DocType PDF
Edition; Page 3; 743-750
IF 5.42
Publisher J. Allergy Clin. Immunol. Pract.
ReleaseDate 2015

Background: Data from the 3 omalizumab pivotal trials inpatients with chronic idiopathic urticaria/chronic spontaneous urticaria (CIU/CSU) represent the largest database of patients reported to date with refractory disease (omalizumab, n[733;placebo, n[242).

Objective: The objective of this study was to compare results from ASTERIA I and II, which included only approved doses ofH1-antihistamine as background therapy based on regulatory authority requirements, to those from GLACIAL, which permitted higher doses of H1-antihistamines as well as other types of background therapy, in aposthocanalysis.

Methods: Efficacy data from the placebo, omalizumab 150-mg, and omalizumab 300-mg treatment arms of ASTERIA I andII were pooled and analyzed (n[162 and n[160, respectively). The 300-mg treatment arm analyses were compared with the analysis of data from GLACIAL (n[252) using analysis of covariance models. The key efficacy endpoint was change from baseline to week 12 in mean weekly itch severity score (ISS);

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429