Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Substance P as an Immunomodulatory Neuropeptide in a Mouse Model for Autoimmune Hair Loss (Alopecia Areata)
Filename | 50. Siebenhaar, Subst.P autoimm. hair loss, JID 2007.pdf |
Filesize | 230.14 KB |
Version | o.050 |
Date added | May 26, 2020 |
Downloaded | 0 times |
Category | Original Work |
Authors | Siebenhaar, F., Sharov, A. A., Peters, E. M. J., Sharova, T. Y., Syska, W., Mardaryev, A. N., Freyschmidt-Paul, P., Sundberg, J. P., Maurer, M. and Botchkarev, V. A. |
Citation | Siebenhaar, F., Sharov, A. A., Peters, E. M. J., Sharova, T. Y., Syska, W., Mardaryev, A. N., Freyschmidt-Paul, P., Sundberg, J. P., Maurer, M. and Botchkarev, V. A.: Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (Alopecia Areata). J. Invest. Dermatol. 2007: 127; 1489-1497. IF: 4.83 |
Corresponding authors | Botchkarev, V. A. |
DocNum | O.50 |
DocType | |
Edition; Page | 127; 1489-1497 |
IF | 4.83 |
Publisher | J. Invest. Dermatol. |
ReleaseDate | 2007 |
Alopecia areata (AA) is an autoimmune disorder of the hair follicle characterized by inflammatory cell infiltrates around actively growing (anagen) hair follicles. Substance P (SP) plays a critical role in the cutaneous
neuroimmune network and influences immune cell functions through the neurokinin-1 receptor (NK-1R). To better understand the role of SP as an immunomodulatory neuropeptide in AA, we studied its expression and
effects on immune cells in a C3H/HeJ mouse model for AA. During early stages of AA development, the number of SP–immunoreactive nerve fibers in skin is increased, compared to non-affected mice. However, during advanced stages of AA, the number of SP-immunoreactive nerves and SP protein levels in skin are decreased, whereas the expression of the SP-degrading enzyme neutral endopeptidase (NEP) is increased, compared to control skin. In AA, NK-1R is expressed on CD8 þ lymphocytes and macrophages accumulating around affected hair follicles. Additional SP supply to the skin of AA-affected mice leads to a significant increase of mast cell degranulation and to accelerated hair follicle regression (catagen), accompanied by an increase of CD8 þ cellsexpressing granzyme B. These data suggest that SP, NEP, and NK-1R serve as important regulators in the molecular signaling network modulating inflammatory response in autoimmune hair loss.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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