Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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The expression of IL-17, in chronic spontaneous urticaria is linked to semaphorin5A
Filename | 416. Lobna et al., IL-17 semaphoron5A, Biomolecules 2021.pdf |
Filesize | 3.16 MB |
Version | o.416 |
Date added | May 31, 2021 |
Downloaded | 0 times |
Category | Original Work |
Tags | chronic spontaneous urticaria, IL-17, mast cells, semaphorin5A, T cells |
Authors | Matanis, L., Eiza, N., Sabag, A., Bejar, J., Giménez-Arnau, A. M., Maurer, M., and Vadasz, Z. |
Citation | Matanis, L., Eiza, N., Sabag, A., Bejar, J., Giménez-Arnau, A. M., Maurer, M., and Vadasz, Z.: The expression of IL-17, in chronic spontaneous urticaria is linked to semaphorin5A. Biomolecules 2021: 11; 373. |
DocNum | o.416 |
DocType | |
Equivalent authors | Matanis, L. and Eiza, N. |
IF | 6.06 |
Publisher | Biomolecules |
ReleaseDate | 2021 |
Corresponding authors | Vadasz, Z. |
Background: Patients with chronic spontaneous urticaria (CSU), an autoimmune disorder, show increased skin expression of IL-17A and can benefit from treatment with the anti-IL-17A biologic secukinumab. The mechanisms that drive IL-17A expression in CSU are currently unknown, but may involve Semaphorin5A (Sema5A).
Objective: To explore the expression, role, and effects of Sema5A in CSU and its link to IL-17A.
Material and Methods: We investigated patients with CSU and healthy controls for skin expression of expressing peripheral T cells.
Results: Sema5A was highly expressed in the skin of CSU patients as compared to healthy control skin. Both CD4+ T cells and mast cells in CSU skin expressed Sema5A, and many of them expressed both Sema5A and IL-17A. Patients with CSU had significantly higher rates of IL-17A-expressing CD4+ T cells as compared to healthy controls. Incubation with Sema5A increased the rates of IL-17A-expressing CD4+ T cells in healthy controls to CSU levels.
Conclusion: Sema5A may drive the expression and effects of IL-17A in CSU. Further studies in larger cohorts are needed to confirm the role of Sema5A in the pathogenesis of CSU and to explore its potential as a therapeutic target.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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