Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

Use: Start with an overview of all publications. Use tag links to list selected documents or to list an entire category, e.g. Original Work, Books, Book Chapters, Reviews. If you know what you are looking for, enter this term in the search field.

The expression of IL-17, in chronic spontaneous urticaria is linked to semaphorin5A

Filename 416. Lobna et al., IL-17 semaphoron5A, Biomolecules 2021.pdf
Filesize 3.16 MB
Version o.416
Date added May 31, 2021
Downloaded 0 times
Category Original Work
Tags chronic spontaneous urticaria, IL-17, mast cells, semaphorin5A, T cells
Authors Matanis, L., Eiza, N., Sabag, A., Bejar, J., Giménez-Arnau, A. M., Maurer, M., and Vadasz, Z.
Citation Matanis, L., Eiza, N., Sabag, A., Bejar, J., Giménez-Arnau, A. M., Maurer, M., and Vadasz, Z.: The expression of IL-17, in chronic spontaneous urticaria is linked to semaphorin5A. Biomolecules 2021: 11; 373.
DocNum o.416
DocType PDF
Equivalent authors Matanis, L. and Eiza, N.
IF 6.06
Publisher Biomolecules
ReleaseDate 2021
Corresponding authors Vadasz, Z.

Background: Patients with chronic spontaneous urticaria (CSU), an autoimmune disorder, show increased skin expression of IL-17A and can benefit from treatment with the anti-IL-17A biologic secukinumab. The mechanisms that drive IL-17A expression in CSU are currently unknown, but may involve Semaphorin5A (Sema5A).

Objective: To explore the expression, role, and effects of Sema5A in CSU and its link to IL-17A.

Material and Methods: We investigated patients with CSU and healthy controls for skin expression of expressing peripheral T cells.

Results: Sema5A was highly expressed in the skin of CSU patients as compared to healthy control skin. Both CD4+ T cells and mast cells in CSU skin expressed Sema5A, and many of them expressed both Sema5A and IL-17A. Patients with CSU had significantly higher rates of IL-17A-expressing CD4+ T cells as compared to healthy controls. Incubation with Sema5A increased the rates of IL-17A-expressing CD4+ T cells in healthy controls to CSU levels.

Conclusion: Sema5A may drive the expression and effects of IL-17A in CSU. Further studies in larger cohorts are needed to confirm the role of Sema5A in the pathogenesis of CSU and to explore its potential as a therapeutic target.

 

(Last update: 12.2023)

Number of original publications in peer-reviewed journals:580
Number of reviews in peer-reviewed journals:210
Number of publications (original work and reviews) in peer-reviewed journals:790
Cumulative IF for original publications in peer-reviewed journals:4196.39
Cumulative IF for reviews in peer-reviewed journals:1409.32
Cumulative IF of publications (original work & reviews) in peer-reviewed journals:5605.71
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023)36836

Download-Information

To be able to download the offered contents, you have to login. If you do not know the login, please write me your request.