Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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The inhibition by levocetirizine and fexofenadine of the histamine-induced wheal and flare response in healthy Caucasian and Japanese volunteers
Filename | 160. Schoepke et al,The inhib.by Levoc.ActDermVen2013.pdf |
Filesize | 1.60 MB |
Version | o.160 |
Date added | June 5, 2020 |
Downloaded | 0 times |
Category | Original Work |
Tags | Caucasian, duration of action, fexofenadine, H1-antihistamines, Japanese, levocetirizine, onset of action, wheal and flare |
Authors | Schoepke, N., Church, M. K., and Maurer, M. |
Citation | Schoepke, N., Church, M. K., and Maurer, M.: The inhibition by levocetirizine and fexofenadine of the histamine-induced wheal and flare response in healthy Caucasian and Japanese volunteers. Acta Derm. Venereol. 2013: 93; 286-293. |
Corresponding authors | Church, M. K. |
DocNum | O.160 |
DocType | |
Edition; Page | 93; 286-293 |
IF | 4.24 |
Publisher | Acta Derm. Venereol. |
ReleaseDate | 2013 |
This randomized, double-blind, placebo-controlled cross- over study compared inhibition by one 5 mg dose of levocetirizine with two 60 mg doses of fexofenadine se- parated by 12 h of histamine-induced wheal and are responses in 9 Caucasian and 9 Japanese healthy male volunteers. Levocetirizine was more inhibitory than fexofenadine on wheal, are and pruritus (p < 0.005). Va- riability, evaluated from the standard deviation of inhi- bition, ranged from 14% to 23.2% for levocetirizine and 65.4% to 112.4% for fexofenadine. Levocetirizine had a faster onset of action (30–90 min versus 2 h), shorter time to maximum effect (3–4 versus 3–6 h) and longer duration of action (at least 24 h versus ~12 h) than fexo- fenadine. The plasma levels of levocetirizine rose more quickly, reached higher levels, were more consistent and decreased slower than those of fexofenadine. There were no clinically signi cant ethnic differences in responsive- ness to the drugs.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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