Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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The role and relevance of mast cells in urticaria

Filename 131. Church et al., Role and relev. MC,ImmunolRev2018.pdf
Filesize 643 KB
Version r.131
Date added June 17, 2020
Downloaded 3 times
Category Reviews
Tags autoallergy, chronic spontaneous urticaria, mast cell, urticaria
Authors Church, M. K., Kolkhir, P., Metz, M., and Maurer, M.
Citation Church, M. K., Kolkhir, P., Metz, M., and Maurer, M.: The role and relevance of mast cells in urticaria. Immunol. Rev. 2018: 282; 232-247.
Corresponding authors Maurer, M.
DocNum r.131
DocType PDF
Edition; Page 282; 232-247
IF 11.29
Publisher Immunol. Rev.
ReleaseDate 2018

This review presents evidence that the skin mast cell, in particular the MCTC subtype, is the primary effector cell in urticaria. Mast cells are located in the upper dermis, the ideal situation for wheal formation and sensory nerve stimulation. Increased numbers of mast cells are found in both lesional and non-lesional skin in CSU and inducible ur- ticaria. Mast cell degranulation in the area of wheals has been demonstrated repeat- edly by light and electron microscopy. Histamine, PGD2 and tryptase are found in the venous blood draining wheal formation. The last 2 are specific for mast cells rather than basophils. Mast cell reactivity is increased in active urticaria by local inflammatory cytokines and neuropeptides. Mast cell cytokines and neuropeptides, particularly nerve growth factor, induce a Th2 type inflammation that is particularly obvious at the sites of whealing. In conclusion, autoimmunity, either of Type 1 viz. IgE antibodies to local autoallergens, or Type 2b, viz. IgG autoantibodies to IgE or its receptor, are con- sidered to be the most frequent causes of CSU. In both cases, the mast cell is likely to be the axial cell in producing the wheals.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429