Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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The role of eosinophils in chronic spontaneous urticaria
Filename | 157. Altrichter et al., Role of eosinophils CSU, JACI2020.pdf |
Filesize | 461.31 KB |
Version | r.157 |
Date added | August 29, 2020 |
Downloaded | 8 times |
Category | Reviews |
Tags | chronic spontaneous urticaria, eosinophils |
Authors | Altrichter, S., Frischbutter, S., Fok, J. S., Kolkhir, P., Jiao, Q., Stahl Skov, P., Metz, M., Church, M. K., and Maurer, M.+ |
Citation | Altrichter, S., Frischbutter, S., Fok, J. S., Kolkhir, P., Jiao, Q., Stahl Skov, P., Metz, M., Church, M. K., and Maurer, M.: The role of eosinophils in chronic spontaneous urticaria. J. Allergy Clin. Immunol. 2020: 145; 1510-1516. |
DocNum | r.157 |
DocType | |
IF | 10.79 |
Publisher | J. Allergy Clin. Immunol. 2020: 145; 1510-1516. |
ReleaseDate | 2020 |
Chronic spontaneous urticaria (CSU) is considered to be primarily a mast cell–driven disease. However, recent evidence suggests that eosinophils may also have an axial role in symptomology. Histologic studies have demonstrated the presence of both eosinophils and eosinophil granules, indicative of activation, in CSU lesions. Although many allergic and inflammatory conditions are associated with a peripheral blood eosinophilia, the converse appears to be the case in CSU, with a peripheral blood eosinopenia being observed in many patients. Possible mechanisms include the depletion of blood eosinophils by recruitment into the skin during active disease and immunologic destruction in the blood. We also address in some detail the interactions between eosinophils and mast cells, particularly the cytokine cross-talk of these cells and mediator release possibly leading to clinical symptoms. Also, activation by eosinophil proteins of the coagulation pathway leads to the generation of thrombin and increased mast cell degranulation. Finally, treatments aimed at reducing eosinophil accumulation and activation, such as the anti–IL-5 antibodies mepolizumab, reslizumab, and benralizumab, have been reported to reduce CSU symptoms. Clearly, a new picture of an important role of eosinophils in the pathogenesis of CSU is emerging. (J Allergy Clin Immunol 2020;145:1510-6.)
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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