Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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The role of eosinophils in chronic spontaneous urticaria

Filename 157. Altrichter et al., Role of eosinophils CSU, JACI2020.pdf
Filesize 461 KB
Version r.157
Date added August 29, 2020
Downloaded 2 times
Category Reviews
Tags chronic spontaneous urticaria, eosinophils
Authors Altrichter, S., Frischbutter, S., Fok, J. S., Kolkhir, P., Jiao, Q., Stahl Skov, P., Metz, M., Church, M. K., and Maurer, M.+
Citation Altrichter, S., Frischbutter, S., Fok, J. S., Kolkhir, P., Jiao, Q., Stahl Skov, P., Metz, M., Church, M. K., and Maurer, M.: The role of eosinophils in chronic spontaneous urticaria. J. Allergy Clin. Immunol. 2020: 145; 1510-1516.
DocNum r.157
DocType PDF
IF TBD (IF 2019: 10.23)
Publisher J. Allergy Clin. Immunol. 2020: 145; 1510-1516.
ReleaseDate 2020

Chronic spontaneous urticaria (CSU) is considered to be primarily a mast cell–driven disease. However, recent evidence suggests that eosinophils may also have an axial role in symptomology. Histologic studies have demonstrated the presence of both eosinophils and eosinophil granules, indicative of activation, in CSU lesions. Although many allergic and inflammatory conditions are associated with a peripheral blood eosinophilia, the converse appears to be the case in CSU, with a peripheral blood eosinopenia being observed in many patients. Possible mechanisms include the depletion of blood eosinophils by recruitment into the skin during active disease and immunologic destruction in the blood. We also address in some detail the interactions between eosinophils and mast cells, particularly the cytokine cross-talk of these cells and mediator release possibly leading to clinical symptoms. Also, activation by eosinophil proteins of the coagulation pathway leads to the generation of thrombin and increased mast cell degranulation. Finally, treatments aimed at reducing eosinophil accumulation and activation, such as the anti–IL-5 antibodies mepolizumab, reslizumab, and benralizumab, have been reported to reduce CSU symptoms. Clearly, a new picture of an important role of eosinophils in the pathogenesis of CSU is emerging. (J Allergy Clin Immunol 2020;145:1510-6.)

(Last update: 02.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 601
Number of original publications in peer-reviewed journals: 432
Number of reviews in peer-reviewed journals: 169
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3326,21
Cumulative IF for original publications in peer-reviewed journals: 2659,47
Cumulative IF for reviews in peer-reviewed journals: 666,74
Citations, Hirsch index: (view on Web of Science) 24104