Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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The role of IL-33 and mast cells in allergy and inflammation

Filename 98. Saluja et al., Role of IL-33, CTA 2015.pdf
Filesize 1 MB
Version r.098
Date added June 25, 2020
Downloaded 1 time
Category Reviews
Tags Allergic asthma, atopic dermatitis, IL-33, MAP kinases, mast cell, MyD88
Authors Saluja, R., Khan, M., Church, M. K., and Maurer, M.
Citation Saluja, R., Khan, M., Church, M. K., and Maurer, M.: The role of IL-33 and mast cells in allergy and inflammation. Clin. Transl. Allergy 2015: 5; 33.
Corresponding authors Saluja, R.
DocNum r.98
DocType PDF
Edition; Page 5; 33
IF N/A
Publisher Clin. Transl. Allergy
ReleaseDate 2015

Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) cytokine family. It is preferentially and constitutively expressed in different structural cells such as epithelial cells, endothelial cells, and smooth muscle cells. During necro- sis of these cells (after tissue injury or cell damage), the IL-33 that is released may be recognized by different types of immune cells, such as eosinophils, basophils and, especially, mast cells. IL-33 needs the specific receptor ST2 (mem- brane-bound receptor) and Interleukin-1 receptor accessory protein heterodimer for its binding, which instigates
the production of different types of cytokines and chemokines that have crucial roles in the exacerbation of allergic diseases and inflammation. IL-33 and mast cells have been influentially associated to the pathophysiology of allergic diseases and inflammation. IL-33 is a crucial regulator of mast cell functions and might be an attractive therapeutic target for the treatment of allergic and inflammatory diseases. In this review, we summarize the current knowledge regarding the roles of IL-33 and mast cells in the pathogenesis of allergies and inflammation.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429