Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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The role of mast cells in neuroinflammation

Filename 75. Nelissen et al,The role of MC in neuroinfl.ACT.NEUROPATH.2013 Review.pdf
Filesize 928 KB
Version r.075
Date added June 26, 2020
Downloaded 0 times
Category Reviews
Tags Experimental autoimmune encephalomyelitis, Inflammation, mast cells, 􏰊 Brain trauma, 􏰊 Brain tumors, 􏰊 Neurodegenerative diseases, 􏰊 Stroke
Authors Nelissen, S., Lemmens, E., Geurts, N., Kramer, P., Maurer, M., Hendriks, J., and Hendrix, S.
Citation Nelissen, S., Lemmens, E., Geurts, N., Kramer, P., Maurer, M., Hendriks, J., and Hendrix, S.: The role of mast cells in neuroinflammation. Acta Neuropathol. 2013: 125; 637-650.
Corresponding authors Hendrix, S
DocNum r.75
DocType PDF
Edition; Page 125; 637-650
IF 9.78
Publisher Acta Neuropathol.
ReleaseDate 2013

Mast cells (MCs) are densely granulated peri- vascular resident cells of hematopoietic origin and well known for their pathogenetic role in allergic and anaphy- lactic reactions. In addition, they are also involved in processes of innate and adaptive immunity. MCs can be activated in response to a wide range of stimuli, resulting in the release of not only pro-inflammatory, but also anti- inflammatory mediators. The patterns of secreted mediators depend upon the given stimuli and microenvironmental conditions, accordingly MCs have the ability to promote or attenuate inflammatory processes. Their presence in the central nervous system (CNS) has been recognized for more than a century. Since then a participation of MCs in various pathological processes in the CNS has been well documented. They can aggravate CNS damage in models of brain ischemia and hemorrhage, namely through increased blood–brain barrier damage, brain edema and hemorrhage formation and promotion of inflammatory responses to such events. In contrast, recent evidence suggests that MCs may have a protective role following traumatic brain injury by degrading pro-inflammatory cytokines via specific proteases. In neuroinflammatory diseases such as multiple sclerosis, the role of MCs seems to be ambiguous. MCs have been shown to be damaging, neuroprotective, or even dispensable, depending on the experimental protocols used. The role of MCs in the for- mation and progression of CNS tumors such as gliomas is complex and both positive and negative relationships between MC activity and tumor progression have been reported. In summary, MCs and their secreted mediators modulate inflammatory processes in multiple CNS pathologies and can thereby either contribute to neurolog- ical damage or confer neuroprotection. This review intends to give a concise overview of the regulatory roles of MCs in brain disease.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429