Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders

Filename 88. Saluja et al., IL33 IL1RL1 axis in MC, Molec.Immun.2014.pdf
Filesize 1 MB
Version r.088
Date added June 25, 2020
Downloaded 1 time
Category Reviews
Tags basophil, IL-1RAcP, IL-1RL1, IL-33, mast cell, Signal transduction
Authors Saluja, R., Ketelaar, M. E., Hawro, T., Church, M. K., Maurer, M., and Nawijn, M. C.
Citation Saluja, R., Ketelaar, M. E., Hawro, T., Church, M. K., Maurer, M., and Nawijn, M. C.: The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders. Mol. Immunol. 2014: 63; 80-85.
Corresponding authors Saluja, R
DocNum r.88
Edition; Page 63; 80-85
IF 2.97
Publisher Mol. Immunol.
ReleaseDate 2014

Interleukin-33 (IL-33) is a recently discovered cytokine that belongs to the IL-1 superfamily and acts as an important regulator in several allergic disorders. It is considered to function as an alarmin, or danger cytokine, that is released upon structural cell damage. IL-33 activates several immune cells, including Th2 cells, mast cells and basophils, following its interaction with a cell surface heterodimer consisting of an IL-1 receptor-related protein ST2 (IL-1RL1) and IL-1 receptor accessory protein (IL-1RAcP). This activation leads to the production of a variety of Th2-like cytokines that mediate allergic-type immune responses. Thus, IL-33 appears to be a double-edged sword because, in addition to its important contribution to host defence, it exacerbates allergic responses, such as allergic rhinitis and asthma. A major purported mechanism of IL-33 in allergy is the activation of mast cells to produce a variety of pro-inflammatory cytokines and chemokines. In this review, we summarize the current knowledge regarding the genetics and physiology of IL-33 and IL-1RL1 and its association with different allergic diseases by focusing on its effects on mast cells and basophils.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429