Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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The urticaria activity score – validity, reliability, and responsiveness

Filename 322. Hawro et al., UAS validity reliability resp., JACIinPract2018.pdf
Filesize 343 KB
Version o.322
Date added June 13, 2020
Downloaded 1 time
Category Original Work
Tags Chronic inducible urticaria, chronic spontaneous urticaria, Disease activity, Minimal important difference, Patient reported outcome, Quality of life, Reliability, Reproducibility, Responsiveness, Smallest detectable change, Urticaria Activity Score, Validity
Authors Hawro, T., Ohanyan, T., Schoepke, N., Metz, M., Peveling-Oberhag, A., Staubach, P., Maurer, M. and Weller, K.
Citation Hawro, T., Ohanyan, T., Schoepke, N., Metz, M., Peveling-Oberhag, A., Staubach, P., Maurer, M. and Weller, K.: The urticaria activity score – validity, reliability, and responsiveness. J. Allergy Clin. Immunol. Pract. 2018: 6; 1185-1190.
Corresponding authors Weller, K.
DocNum O.322
DocType PDF
Edition; Page 6; 1185-1190
IF 7.55
Publisher J. Allergy Clin. Immunol. Pract.
ReleaseDate 2018

BACKGROUND: Chronic spontaneous urticaria is characterized by fluctuating symptoms. Its activity is assessed with the urticaria activity score (UAS). Two versions of the urticaria activity score used for 7 consecutive days (UAS7) are available: (1) The guideline-recommended UAS7, with once- daily documentation, and (2) the UAS7TD, with twice-daily documentation.

OBJECTIVE: To better characterize both UAS7 versions with regard to their validity, reliability, sensitivity to change, minimal important difference (MID), and smallest detectable change (SDC).

METHODS: One hundred thirty adult patients with chronic spontaneous urticaria completed both UAS7 versions, the Patients Global Assessment (PatGA) of disease activity, the Urticaria Control Test (UCT), the Chronic Urticaria Quality of Life Questionnaire, and the Dermatology Life Quality Index before and after the initiation of omalizumab therapy. Physicians completed a Physician Global Assessment of disease activity.

RESULTS: The UAS7 and the UAS7TD showed high correlation with the activity anchor PatGA (r [ 0.568, P < .001 and r[0.605,P<.001)andtheUCT(r[L0.580,P<.001and r [ L0.585, P < .001). The wheal and pruritus scores of the UAS7 and the UAS7TD exhibited respectable internal consistency and, in each UAS7 version, correlated well with each other (Cronbach a [ 0.78, r [ 0.640, P < .001, and Cronbach a [ 0.77, r [ 0.626, P < .001). Changes in the UAS7 and UAS7TD correlated well with PatGA changes (r [ 639, P < .001, and r [ .763, P < .001) and with UCT changes (r [ L0.642, P < .001, and r [ L0.703, P < .001). The MID was 11 for the UAS7 (SDC [ 12) and 12 for the UAS7TD (SDC [ 11).

CONCLUSIONS: The UAS7 and UAS7TD show good and comparable clinimetric properties, including good sensitivity to change, and similar MIDs.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429