Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Treatment of HAE Attacks in the Icatibant Outcome Survey: An Analysis of Icatibant Self-Administration versus Administration by Health Care Professionals

Filename 212. Hernandez et al., HAE in IOS, IAAI 2015.pdf
Filesize 149.91 KB
Version o.212
Date added July 29, 2020
Downloaded 2 times
Category Original Work
Tags bradykinin B2 receptor antagonist, C1 inhibitor deficiency, Hereditary angio-oedema, Icatibant, Icatibant Outcome Survey, Oedema, self-administration, therapy
Authors Hernández Fernández de Rojas, D., Ibáňez, E., Longhurst, H., Maurer, M. Fabien, V., Aberer, W., Bouillet, L., Zanichelli, A., and Caballero, T.
Citation Hernández Fernández de Rojas, D.+, Ibáňez, E., Longhurst, H., Maurer, M. Fabien, V., Aberer, W., Bouillet, L., Zanichelli, A., and Caballero, T.: Treatment of HAE attacks in the icatibant outcome survey: an analysis of icatibant self-administration versus administration by health care professionals. Int. Arch. Allergy Immunol. 2015: 167; 21-28.
Corresponding authors Hernández Fernández de Rojas, D.
DocNum O.212
DocType PDF
Edition; Page 167; 21-28
IF 2.67
Publisher Int. Arch. Allergy Immunol.
ReleaseDate 2015

Background: Icatibant, a selective bradykinin B2 receptor antagonist for the treatment of acute hereditary angio-oedema (HAE) attacks in adults, can be administered by health care professionals (HCPs) or self-administered. This analysis compared characteristics and outcomes of acute HAE at-tacks treated with self-administered and HCP-administered icatibant in a real-world setting.

Methods: The Icatibant Out-come Survey (Shire, Zug, Switzerland; NCT01034969) is an international observational study monitoring the safety and effectiveness of icatibant treatment. Descriptive retrospective analyses were performed (February 2008 to December 2012).

Results: Icatibant was used in 652 attacks in 170 patients with HAE type I/II. Most icatibant injections were self-administered (431/652, 68.5%). The proportion of self-treat-ed attacks increased over time (40.3% in 2009 vs. 89.7% in 2012). The median time to administration was significantly shorter in self- versus HCP-treated attacks (1.5 vs. 2.4 h; p = 0.016). Earlier treatment (<2 h after onset) was significantly associated with a shorter median time to resolution (2.5 vs. 5.0 h; p = 0.032) and attack duration (3.0 vs. 14.0 h; p < 0.0001), regardless of administration method. Patients self-administered icatibant for attacks of all severities; overall, 34.7% of severe and 30.2% of very severe attacks were HCP treated. Logistic regression analysis did not find use of long-term prophylaxis, attack location or gender to be predictive for self-administration.

Conclusions: The proportion of HAE attacks treated with self-administered icatibant increased over time. Patients successfully self-administered icatibant for a wide variety of HAE attacks, demonstrating that icatibant is generally well tolerated and effective for self-admin-istration. Self-administration of icatibant provides a complementary option to HCP administration, enabling optimization of patient care.

 

(Last update: 12.2023)

Number of original publications in peer-reviewed journals:580
Number of reviews in peer-reviewed journals:210
Number of publications (original work and reviews) in peer-reviewed journals:790
Cumulative IF for original publications in peer-reviewed journals:4196.39
Cumulative IF for reviews in peer-reviewed journals:1409.32
Cumulative IF of publications (original work & reviews) in peer-reviewed journals:5605.71
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023)36836

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