Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

Use: Start with an overview of all publications. Use tag links to list selected documents or to list an entire category, e.g. Original Work, Books, Book Chapters, Reviews. If you know what you are looking for, enter this term in the search field.

Treatment of HAE Attacks in the Icatibant Outcome Survey: An Analysis of Icatibant Self-Administration versus Administration by Health Care Professionals

Filename 212. Hernandez et al., HAE in IOS, IAAI 2015.pdf
Filesize 150 KB
Version o.212
Date added July 29, 2020
Downloaded 1 time
Category Original Work
Tags bradykinin B2 receptor antagonist, C1 inhibitor deficiency, Hereditary angio-oedema, Icatibant, Icatibant Outcome Survey, Oedema, self-administration, therapy
Authors Hernández Fernández de Rojas, D., Ibáňez, E., Longhurst, H., Maurer, M. Fabien, V., Aberer, W., Bouillet, L., Zanichelli, A., and Caballero, T.
Citation Hernández Fernández de Rojas, D.+, Ibáňez, E., Longhurst, H., Maurer, M. Fabien, V., Aberer, W., Bouillet, L., Zanichelli, A., and Caballero, T.: Treatment of HAE attacks in the icatibant outcome survey: an analysis of icatibant self-administration versus administration by health care professionals. Int. Arch. Allergy Immunol. 2015: 167; 21-28.
Corresponding authors Hernández Fernández de Rojas, D.
DocNum O.212
DocType PDF
Edition; Page 167; 21-28
IF 2.67
Publisher Int. Arch. Allergy Immunol.
ReleaseDate 2015

Background: Icatibant, a selective bradykinin B2 receptor antagonist for the treatment of acute hereditary angio-oedema (HAE) attacks in adults, can be administered by health care professionals (HCPs) or self-administered. This analysis compared characteristics and outcomes of acute HAE at-tacks treated with self-administered and HCP-administered icatibant in a real-world setting.

Methods: The Icatibant Out-come Survey (Shire, Zug, Switzerland; NCT01034969) is an international observational study monitoring the safety and effectiveness of icatibant treatment. Descriptive retrospective analyses were performed (February 2008 to December 2012).

Results: Icatibant was used in 652 attacks in 170 patients with HAE type I/II. Most icatibant injections were self-administered (431/652, 68.5%). The proportion of self-treat-ed attacks increased over time (40.3% in 2009 vs. 89.7% in 2012). The median time to administration was significantly shorter in self- versus HCP-treated attacks (1.5 vs. 2.4 h; p = 0.016). Earlier treatment (<2 h after onset) was significantly associated with a shorter median time to resolution (2.5 vs. 5.0 h; p = 0.032) and attack duration (3.0 vs. 14.0 h; p < 0.0001), regardless of administration method. Patients self-administered icatibant for attacks of all severities; overall, 34.7% of severe and 30.2% of very severe attacks were HCP treated. Logistic regression analysis did not find use of long-term prophylaxis, attack location or gender to be predictive for self-administration.

Conclusions: The proportion of HAE attacks treated with self-administered icatibant increased over time. Patients successfully self-administered icatibant for a wide variety of HAE attacks, demonstrating that icatibant is generally well tolerated and effective for self-admin-istration. Self-administration of icatibant provides a complementary option to HCP administration, enabling optimization of patient care.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429