Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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What is the physiological function of mast cells?
Filename | 05. Maurer, PhysFunctions of MCs, ExpDermatol.2003.pdf |
Filesize | 1.58 MB |
Version | r.005 |
Date added | June 15, 2020 |
Downloaded | 0 times |
Category | Reviews |
Tags | mast cells |
Authors | Maurer, M., Theoharides, T., Granstein, R., Kovanen, P. T., Bischoff, S. C., Befus, D., Vliagoftis, H., Forsythe, P., Kambe, N., Miyachi, Y., Henz, B. M., Piliponsky, A. M., Levi-Schaffer, F., Kitamura, Y., Bienenstock, J., and Galli, S. J. |
Citation | Maurer, M., Theoharides, T., Granstein, R., Kovanen, P. T., Bischoff, S. C., Befus, D., Vliagoftis, H., Forsythe, P., Kambe, N., Miyachi, Y., Henz, B. M., Piliponsky, A. M., Levi-Schaffer, F., Kitamura, Y., Bienenstock, J., and Galli, S. J.: What is the physiological function of mast cells? Exp. Dermatol. 2003: 12; 886-910. |
DocNum | R.5 |
DocType | |
Edition; Page | 12; 886-910. |
IF | 2.04 |
Publisher | Exp. Dermatol. |
ReleaseDate | 2003 |
Under physiological conditions, skin mast cells preferentially localize around nerves, blood vessels and hair follicles. This observation, which dates back to Paul Ehrlich, intuitively suggests that these enigmatic, multifacetted protagonists of natural immunity are functionally relevant to many more aspects of tissue physiology than just to the generation of inflammatory and vasodilatory responses to IgE-dependent environmental antigens. And yet, for decades, mainstream-mast cell research has been dominated by a focus on the – undisputedly prominent and important – mast cell functions in type I immune responses and in the pathogenesis and management of allergic diseases. Certainly, it is hard to believe that the very large and rather selectively distributed number of mast cells in normal, uninflamed, non-infected, non-traumatized mammalian skin or mucosal tissue is simply hanging around there lazily day and night, just to wait for the odd allergen or parasite-associated antigen to come by so the mast cell can finally swing into action. Indeed, the past decade has witnessed a renaissance of mast cell research ‘beyond allergy’, along with a more systematic exploration of the surprisingly wide range of physiological functions that mast cells may be involved in. The current debate sketches many of the exciting new horizons that have recently come into our vision during this intriguing, ongoing search.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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